SCHEMBL27140994

SCHEMBL27140994

C=CC(=O)Nc1cc2c(Nc3cc(-c4ccco4)ccc3OC)ncnc2cc1OCCCOC

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.57
KDR P35968 14/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30822103 1.00 EGFR (0.57) EGFRKDR
SCHEMBL30822073 0.96 EGFR (0.62) EGFRKDR
SCHEMBL24714517 0.96 EGFR (0.62) EGFRKDR
SCHEMBL27140470 0.92 EGFR (0.57) EGFRKDR
SCHEMBL30822096 0.92 EGFR (0.57) EGFRKDR
SCHEMBL27136359 0.88 EGFR (0.67) EGFRKDR
SCHEMBL30822099 0.88 EGFR (0.67) EGFRKDR
SCHEMBL30822056 0.87 EGFR (0.70) EGFRKDR
SCHEMBL27136117 0.87 EGFR (0.70) EGFRKDR
SCHEMBL24714706 0.85 EGFR (0.59) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4328222-A1 HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF Voronoi Inc. (KR) 2024-02-28 EP claimed
EP-4328222-A1 HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF Voronoi Inc. (KR) 2024-02-28 EP disclosed