Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 8/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977695 | 0.85 | SYK (0.67) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL14923870 | 0.81 | SYK (0.69) | SYKKCNH2AURKBZAP70FER | |
| SCHEMBL2732376 | 0.80 | SYK (0.54) | SYKKCNH2AURKBZAP70FER | |
| SCHEMBL2714184 | 0.78 | FER (0.47) | SYKKCNH2AURKBZAP70FER | |
| SCHEMBL2712715 | 0.76 | KDM4E (0.44) | FERMAPK1 | |
| SCHEMBL18925865 | 0.76 | SYK (0.64) | SYKKCNH2AURKBZAP70FER | |
| SCHEMBL14911106 | 0.75 | SYK (0.58) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL14911107 | 0.75 | SYK (0.58) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL14977815 | 0.74 | STAT6 (0.59) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL16164019 | 0.74 | FER (0.66) | SYKKCNH2AURKBFERMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |