Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 6/20 | 0.61 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977815 | 0.88 | STAT6 (0.59) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL14977488 | 0.88 | SYK (0.58) | SYKKCNH2AURKBZAP70 | |
| SCHEMBL2714185 | 0.85 | SYK (0.48) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL12137100 | 0.83 | SYK (0.79) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL1354433 | 0.82 | SYK (0.86) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL29794716 | 0.81 | SYK (1.00) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL2383949 | 0.81 | SYK (1.00) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL14975932 | 0.80 | SYK (0.72) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL4713176 | 0.79 | SYK (0.81) | SYKKCNH2AURKBZAP70STAT6 | |
| SCHEMBL4713431 | 0.78 | SYK (0.79) | SYKKCNH2AURKBZAP70STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782580-A1 | SELECTIVE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078468-A1 | SELECTIVE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |