Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.51 |
| ▸ | FER | P16591 | 5/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714438 | 0.82 | SYK (0.54) | SYKFER | |
| SCHEMBL2714437 | 0.82 | SYK (0.54) | SYKFER | |
| SCHEMBL18925404 | 0.76 | FER (0.64) | SYKFER | |
| SCHEMBL5026375 | 0.76 | FER (0.64) | SYKFER | |
| SCHEMBL2713236 | 0.74 | SYK (0.54) | SYK | |
| SCHEMBL2715583 | 0.73 | SYK (0.50) | SYKFERJAK1 | |
| SCHEMBL1351953 | 0.67 | SYK (1.00) | SYK | |
| SCHEMBL1351956 | 0.67 | SYK (1.00) | SYK | |
| SCHEMBL9102447 | 0.66 | SYK (0.66) | SYKFER | |
| SCHEMBL2732113 | 0.66 | SYK (0.49) | SYKFERJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |