Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22495173 | 1.00 | CYP2D6 (0.45) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL21071356 | 1.00 | CYP2D6 (0.45) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL30824549 | 1.00 | CYP2D6 (0.45) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| Hydrochloric Acid SCHEMBL31482194 | 0.98 | LMNA (0.47) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL1690313 | 0.86 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL17676691 | 0.83 | CYP2D6 (0.38) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL28205012 | 0.83 | CYP2D6 (0.39) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL23006304 | 0.81 | CYP2D6 (0.41) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL28825223 | 0.81 | S1PR3 (0.38) | CYP2D6CYP1A2CYP3A4NFKB1PNMT | |
| SCHEMBL1514943 | 0.81 | S1PR3 (0.38) | CYP2D6CYP1A2CYP3A4NFKB1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | CYP2D6 2332/4885CYP1A2 1642/4885CYP3A4 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.