Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15656249 | 0.82 | ALDH1A1 (0.77) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL5960395 | 0.81 | ALDH1A1 (0.76) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL15656246 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| Hydrochloric Acid SCHEMBL21847655 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL13737397 | 0.77 | ALDH1A1 (0.78) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL15655954 | 0.75 | TSHR (0.57) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL30029170 | 0.74 | TSHR (0.46) | ALDH1A1TSHRMAPK1POLBHTT | |
| SCHEMBL30029625 | 0.74 | ALDH1A1 (0.60) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL1080897 | 0.74 | ALDH1A1 (0.56) | ALDH1A1TSHRMAPK1LMNANPC1 | |
| SCHEMBL26659222 | 0.71 | ALDH1A1 (0.51) | ALDH1A1MAPK1LMNANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326274-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022225828-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2022-10-27 | — | — | WO | disclosed |