Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.34 |
| ▸ | LPL | P06858 | 8/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22632425 | 0.82 | NPC1 (0.41) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL18189926 | 0.82 | NPC1 (0.37) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL29414706 | 0.82 | NPC1 (0.41) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL30506908 | 0.80 | NPC1 (0.35) | NPC1 | |
| SCHEMBL25316750 | 0.80 | NPC1 (0.35) | NPC1 | |
| SCHEMBL29513926 | 0.80 | IRAK4 (0.36) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL29835702 | 0.80 | IRAK4 (0.38) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL25346913 | 0.80 | IRAK4 (0.36) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL26919614 | 0.80 | IRAK4 (0.38) | NPC1CA1CA2CA9IRAK4 | |
| SCHEMBL16277686 | 0.77 | LIPG (0.38) | NPC1CA1CA2CA9LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |