Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890536 | 0.79 | PIK3CD (0.59) | PIK3CDHSP90AA1HSP90AB1BRD9BAZ2B | |
| SCHEMBL890481 | 0.74 | PIK3CD (0.54) | PIK3CDHSP90AA1HSP90AB1BRD9BAZ2B | |
| SCHEMBL3959308 | 0.70 | MAPT (0.53) | MAPTALDH1A1KDM4EGLAGAA | |
| SCHEMBL890633 | 0.69 | PIK3CD (0.68) | PIK3CD | |
| SCHEMBL14106369 | 0.68 | MAPT (0.51) | MAPTPOLBDPP4ALDH1A1KDM4E | |
| SCHEMBL3961340 | 0.68 | MAPT (0.53) | MAPTPOLBALDH1A1KDM4EGLA | |
| SCHEMBL3955336 | 0.65 | ENPP2 (0.48) | MAPTPOLBKDM4EGAASMN1; SMN2 | |
| SCHEMBL3959106 | 0.64 | ENPP2 (0.50) | MAPTPOLBALDH1A1KDM4EGAA | |
| SCHEMBL3955153 | 0.64 | MAPT (0.51) | MAPTPOLBDPP4ALDH1A1KDM4E | |
| SCHEMBL18305006 | 0.64 | BAZ2B (0.46) | PIK3CDHSP90AA1HSP90AB1BRD9BAZ2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445898-A2 | 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES AS PI3K INHIBITORS | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151735-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |