SCHEMBL2715434 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	SYK	P43405	10/20	0.40

▸	EGFR	P00533	6/20	0.40

▸	BTK	Q06187	4/20	0.36

▸	JAK2	O60674	1/20	0.35

▸	LYN	P07948	1/20	0.35

▸	TEC	P42680	1/20	0.35

▸	TXK	P42681	1/20	0.35

▸	BMX	P51813	1/20	0.35

▸	JAK3	P52333	1/20	0.35

▸	CD69	Q07108	1/20	0.35

▸	ITK	Q08881	1/20	0.35

▸	SIRT2	Q8IXJ6	1/20	0.35

▸	FBP1	P09467	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2715431	1.00	SYK (0.40)	SYKEGFRBTKJAK2LYN
SCHEMBL2718804	0.90	SYK (0.42)	SYKEGFRBTKJAK2LYN
SCHEMBL2715377	0.90	SYK (0.42)	SYKEGFRBTKJAK2LYN
SCHEMBL2715849	0.88	PIK3CA (0.38)	SYK
SCHEMBL2716094	0.86	EGFR (0.38)	SYKEGFRITK
SCHEMBL2718568	0.85	SYK (0.41)	SYK
SCHEMBL2715948	0.83	SYK (0.46)	SYKBTK
SCHEMBL2715944	0.83	SYK (0.46)	SYKBTK
SCHEMBL2719062	0.82	GAA (0.44)	SYKJAK2
SCHEMBL2717572	0.81	EGFR (0.38)	SYKEGFRITK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012061415-A1	OXYPYRIMIDINES AS SYK MODULATORS	PORTOLA PHARMACEUTICALS, INC. (US)	2012-05-10	—	—	WO	disclosed