Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715948 | 1.00 | SYK (0.46) | SYKCDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL2715679 | 0.91 | SYK (0.39) | SYKCDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL2718568 | 0.87 | SYK (0.41) | SYK | |
| SCHEMBL2715849 | 0.83 | PIK3CA (0.38) | SYK | |
| SCHEMBL2715434 | 0.83 | SYK (0.40) | SYKBTK | |
| SCHEMBL2715431 | 0.83 | SYK (0.40) | SYKBTK | |
| SCHEMBL2716094 | 0.82 | EGFR (0.38) | SYK | |
| SCHEMBL2719062 | 0.79 | GAA (0.44) | SYKDYRK1A | |
| SCHEMBL2717572 | 0.78 | EGFR (0.38) | SYK | |
| SCHEMBL2715377 | 0.77 | SYK (0.42) | SYKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |