Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002520 | 1.00 | KRAS (0.55) | KRAS | |
| SCHEMBL29572675 | 0.93 | KRAS (0.48) | KRAS | |
| SCHEMBL25414132 | 0.93 | KRAS (0.48) | KRAS | |
| SCHEMBL25829878 | 0.93 | KRAS (0.52) | KRAS | |
| SCHEMBL29963067 | 0.93 | KRAS (0.52) | KRAS | |
| SCHEMBL29907439 | 0.93 | KRAS (0.52) | KRAS | |
| SCHEMBL27149541 | 0.90 | KRAS (0.52) | KRAS | |
| SCHEMBL31129086 | 0.89 | KRAS (0.49) | KRAS | |
| SCHEMBL30109010 | 0.89 | KRAS (0.55) | KRAS | |
| SCHEMBL27138934 | 0.89 | KRAS (0.55) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116113416-B | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4328229-A2 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-02-28 | — | — | EP | disclosed |
| CN-116848111-A | KRAS inhibitor key intermediate and preparation method thereof | 浙江海正药业股份有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116113416-A | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-115304602-A | Pyrazinopyrazinonaphthyridinedione derivatives, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-115124533-A | Tetracyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| WO-2022199170-A1 | TETRACYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 浙江海正药业股份有限公司 | 2022-09-29 | — | — | WO | disclosed |