Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25829878 | 1.00 | KRAS (0.52) | KRAS | |
| SCHEMBL29963067 | 1.00 | KRAS (0.52) | KRAS | |
| SCHEMBL25829796 | 0.94 | KRAS (0.50) | KRAS | |
| SCHEMBL29907534 | 0.94 | KRAS (0.50) | KRAS | |
| SCHEMBL30582067 | 0.93 | KRAS (0.46) | KRAS | |
| SCHEMBL26321789 | 0.93 | KRAS (0.46) | KRAS | |
| SCHEMBL30002520 | 0.93 | KRAS (0.55) | KRAS | |
| SCHEMBL27154366 | 0.93 | KRAS (0.55) | KRAS | |
| SCHEMBL29828318 | 0.91 | KRAS (0.49) | KRAS | |
| SCHEMBL29907419 | 0.91 | KRAS (0.49) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4053118-B1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | GENFLEET THERAPEUTICS SHANGHAI INC (CN) | 2024-10-09 | — | — | EP | disclosed |
| US-12054497-B2 | Substituted heterocyclic fused cyclic compound, preparation method therefor and pharmaceutical use thereof | Genfleet Therapeutics (Shanghai)Inc. (CN) | 2024-08-06 | — | — | US | disclosed |
| US-20240158417-A1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2024-05-16 | — | — | US | disclosed |
| EP-4328229-A2 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2024-02-28 | — | — | EP | disclosed |
| CN-116848111-A | KRAS inhibitor key intermediate and preparation method thereof | 浙江海正药业股份有限公司 | 2023-10-03 | — | — | CN | disclosed |
| US-20230084095-A1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2023-03-16 | — | — | US | disclosed |
| WO-2022198904-A1 | KEY INTERMEDIATE OF KRAS INHIBITOR AND PREPARATION METHOD THEREFOR | 浙江海正药业股份有限公司 | 2022-09-29 | — | — | WO | disclosed |
| EP-4053118-A1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2022-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230084095-A1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | KRAS, NRAS, HRAS | KRAS 1/4885 |
| US-20240158417-A1 | SUBSTITUTED HETEROCYCLIC FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | KRAS, NRAS, HRAS | KRAS 1/4885 |
| US-12054497-B2 | Substituted heterocyclic fused cyclic compound, preparation method therefor and pharmaceutical use thereof | KRAS, NRAS, HRAS | KRAS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.