Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP1 | P63208 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | DTYMK | P23919 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31046329 | 1.00 | POLB (0.57) | POLBGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL3436722 | 0.87 | POLB (0.57) | POLBGPR119TRPA1TRPV1KIT | |
| SCHEMBL29741422 | 0.86 | POLB (0.56) | POLBGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30591901 | 0.86 | POLB (0.56) | POLBGPR119TRPA1TRPV1KIT | |
| SCHEMBL761090 | 0.86 | POLB (0.56) | POLBGPR119TRPA1TRPV1KIT | |
| SCHEMBL11356927 | 0.86 | HRH3 (0.56) | POLBGPR119TRPA1TRPV1KIT | |
| SCHEMBL2421627 | 0.86 | TRPA1 (0.68) | POLBGPR119TRPA1TRPV1 | |
| SCHEMBL1433068 | 0.86 | POLB (0.56) | POLBGPR119TRPA1TRPV1KIT | |
| SCHEMBL3335222 | 0.86 | POLB (0.56) | POLBGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL2560776 | 0.86 | POLB (0.56) | POLBGPR119TRPA1TRPV1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |