⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7019757 | 0.57 | — | — | |
| Hydrochloric Acid SCHEMBL1300445 | 0.57 | — | — | |
| SCHEMBL29588443 | 0.57 | — | — | |
| Hydrochloric Acid SCHEMBL1166676 | 0.56 | — | — | |
| SCHEMBL3394905 | 0.53 | MKNK1 (0.36) | — | |
| SCHEMBL25259343 | 0.53 | CHRNB2 (0.35) | — | |
| SCHEMBL1190111 | 0.53 | GRM5 (0.36) | — | |
| SCHEMBL8221928 | 0.53 | — | — | |
| SCHEMBL30672210 | 0.53 | MKNK1 (0.36) | — | |
| SCHEMBL29588561 | 0.53 | MKNK2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228506-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-11 | — | — | US | disclosed |
| US-20240228506-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-11 | — | — | US | disclosed |
| EP-4329766-A1 | RIPK1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022231928-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2022-11-03 | — | — | WO | disclosed |