SCHEMBL2715928

SCHEMBL2715928

CC(C)CC(Nc1nc(Nc2cccc(OC(F)(F)F)c2)c(C(N)=O)c(=O)[nH]1)C(N)=O

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 14/20 0.42
P2RX3 P56373 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2715926 1.00 SYK (0.42) SYKP2RX3
SCHEMBL10271735 0.91 SYK (0.42) SYKP2RX3
SCHEMBL2718425 0.91 SYK (0.44) SYK
SCHEMBL2718419 0.91 SYK (0.44) SYK
SCHEMBL2731588 0.90 SYK (0.41) SYK
SCHEMBL2731593 0.90 SYK (0.41) SYK
SCHEMBL2716671 0.90 SYK (0.51) SYK
SCHEMBL2716675 0.90 SYK (0.51) SYK
SCHEMBL2731573 0.86 SYK (0.44) SYK
SCHEMBL2717554 0.86 SYK (0.44) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012061415-A1 OXYPYRIMIDINES AS SYK MODULATORS PORTOLA PHARMACEUTICALS, INC. (US) 2012-05-10 WO disclosed