Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914798 | 1.00 | BACE1 (0.36) | BACE1LTA4HALDH1A1GAAKDM4E | |
| SCHEMBL27159901 | 0.89 | BACE1 (0.39) | BACE1LTA4HALDH1A1KDM4E | |
| SCHEMBL29914919 | 0.89 | BACE1 (0.39) | BACE1LTA4HALDH1A1KDM4E | |
| SCHEMBL29914841 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL29914947 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL29914828 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL27159722 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL27159728 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL27160127 | 0.83 | BACE1 (0.37) | BACE1LTA4H | |
| SCHEMBL29914916 | 0.80 | MGLL (0.36) | BACE1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |