Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715326 | 0.79 | PIK3CD (0.51) | MAPTPKMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL890677 | 0.77 | HTT (0.50) | MAPTPKMHTTALDH1A1LMNA | |
| SCHEMBL890602 | 0.77 | HTT (0.57) | MAPTPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL890479 | 0.72 | HTT (0.43) | MAPTHTTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL890805 | 0.71 | HTT (0.44) | MAPTPKMHTTALDH1A1LMNA | |
| SCHEMBL890492 | 0.69 | PIK3CD (0.56) | MAPTHTTALDH1A1SMN1; SMN2BACE1 | |
| SCHEMBL890562 | 0.68 | HTT (0.53) | MAPTPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18364643 | 0.67 | MAPT (0.52) | MAPTPKMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL890653 | 0.67 | PIK3CD (0.57) | MAPTPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL16585327 | 0.67 | PIK3CD (0.45) | PKMHTTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042497-A2 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |
| EP-2445898-A2 | 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES AS PI3K INHIBITORS | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151735-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |