Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27224976 | 0.89 | MAPK8 (0.43) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL25122796 | 0.84 | ALDH1A1 (0.41) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL1226594 | 0.80 | MEN1 (0.49) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL2622287 | 0.77 | MEN1 (0.49) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL26161013 | 0.77 | SYK (0.49) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL31360665 | 0.77 | MEN1 (0.49) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL22174935 | 0.77 | MEN1 (0.46) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL4715183 | 0.76 | MEN1 (0.45) | MEN1KMT2AGABBR2CYP1A2CYP2C9 | |
| SCHEMBL27224889 | 0.75 | JAK1 (0.44) | MEN1KMT2AMERTKSYKJAK3 | |
| SCHEMBL23340833 | 0.75 | SYK (0.58) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715904-A | CDK2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |