Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 6/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29991124 | 0.87 | RIPK2 (0.40) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL25122990 | 0.87 | RIPK2 (0.40) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL25122419 | 0.85 | LRRK2 (0.47) | LRRK2CDK2RIPK2ACVR1NOD2 | |
| SCHEMBL25122423 | 0.84 | RIPK2 (0.39) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL27360240 | 0.83 | CCNE1 (0.44) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL27359840 | 0.82 | WEE1 (0.37) | WEE1CCND3CDK4CCND1CCND2 | |
| SCHEMBL27359843 | 0.82 | RIPK2 (0.38) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL27360006 | 0.82 | PTK2 (0.50) | LRRK2FGFR1EGFRPTK2SRC | |
| SCHEMBL27361790 | 0.82 | PSEN1 (0.45) | WEE1LRRK2CCND3CDK4CCND1 | |
| SCHEMBL27359929 | 0.81 | CCND1 (0.38) | WEE1LRRK2CCND3CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |