Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.44 |
| ▸ | EGFR | P00533 | 7/20 | 0.44 |
| ▸ | WEE1 | P30291 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 5/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30836989 | 0.89 | CDK4 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27229104 | 0.89 | CDK4 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27229116 | 0.85 | CDK4 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30836977 | 0.85 | CDK4 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25122990 | 0.83 | RIPK2 (0.40) | FGFR1EGFRWEE1SRCFGFR4 | |
| SCHEMBL29991124 | 0.83 | RIPK2 (0.40) | FGFR1EGFRWEE1SRCFGFR4 | |
| SCHEMBL25122419 | 0.83 | LRRK2 (0.47) | ACVR1LRRK2RIPK2PTK6CCNE1 | |
| SCHEMBL25122423 | 0.82 | RIPK2 (0.39) | FGFR1EGFRWEE1LIMK1ACVR1 | |
| SCHEMBL27358404 | 0.82 | FGFR1 (0.42) | FGFR1EGFRWEE1SRCFGFR4 | |
| SCHEMBL27166404 | 0.82 | WEE1 (0.47) | FGFR1EGFRWEE1SRCFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |