Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.52 |
| ▸ | NOS3 | P29474 | 7/20 | 0.52 |
| ▸ | NOS1 | P29475 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28267332 | 0.80 | MAPT (0.56) | NOS2NOS3NOS1MAPTTDP1 | |
| SCHEMBL17995540 | 0.78 | ESR1 (0.36) | NOS2NOS3NOS1 | |
| SCHEMBL12015758 | 0.74 | NOS2 (0.59) | NOS2NOS3NOS1HRH3MEN1 | |
| SCHEMBL798760 | 0.73 | PDE2A (0.33) | NOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL26816606 | 0.73 | NOS2 (0.41) | NOS2NOS3NOS1MAPTTDP1 | |
| SCHEMBL7769935 | 0.72 | NOS2 (0.63) | NOS2NOS3NOS1HRH3MEN1 | |
| SCHEMBL18011660 | 0.72 | NOS2 (0.48) | NOS2NOS3NOS1MAPTTDP1 | |
| SCHEMBL2719526 | 0.72 | NOS2 (0.57) | NOS2NOS3NOS1MAPTTDP1 | |
| SCHEMBL2717960 | 0.72 | NOS2 (0.57) | NOS2NOS3NOS1HRH3MEN1 | |
| SCHEMBL21937782 | 0.72 | CYP3A4 (0.57) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |