Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717867 | 0.94 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAMAP4K4 | |
| SCHEMBL2719382 | 0.91 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717381 | 0.90 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CGPIK3CAMAP4K4 | |
| SCHEMBL2721475 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717260 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CGPIK3CAMAP4K4 | |
| SCHEMBL4096955 | 0.85 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAMAP4K4 | |
| SCHEMBL2718894 | 0.84 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2721364 | 0.84 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2720617 | 0.82 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL4093051 | 0.82 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | claimed |
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |