SCHEMBL27174759

SCHEMBL27174759

CC(=O)OC[C@@]1(COCCOCCOCCO[Si](C(C)C)(C(C)C)C(C)C)O[C@@H](n2cnc3c(=O)[nH]c(NC(=O)C(C)C)nc32)[C@H](OC(C)=O)[C@@H]1OC(C)=O

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ TSHR P16473 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ TAS1R3 Q7RTX0 2/20 0.38
▸ TAS1R1 Q7RTX1 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.35
▸ LMNA P02545 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ HINT1 P49773 1/20 0.32
▸ ACHE P22303 2/20 0.32
▸ MAPK1 P28482 1/20 0.31
▸ HBB P68871 1/20 0.31
▸ TAAR1 Q96RJ0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29546506 0.98 MEN1 (0.40) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL29546511 0.93 KDM4E (0.43) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL29546557 0.91 KDM4E (0.40) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL2157716 0.83 KDM4E (0.41) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL29546748 0.81 KDM4E (0.38) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL25401401 0.76 KDM4E (0.41) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL25401406 0.76 KDM4E (0.41) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL16648560 0.76 KDM4E (0.42) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL17000749 0.76 KDM4E (0.42) MEN1KMT2ATSHRKDM4ETAS1R3
SCHEMBL26269040 0.75 KDM4E (0.45) MEN1KMT2ATSHRKDM4ETAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240092819-A1 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR SANOFI SA (FR) 2024-03-21 — — US disclosed
EP-4232455-A2 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR Sanofi (FR) 2023-08-30 — — EP disclosed
WO-2022084331-A2 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR SANOFI (FR) 2022-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092819-A1 NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR ASGR1, HAVCR2, SIGLEC7 MEN1 4849/4885KMT2A 3800/4885TSHR 487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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