Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559274 | 0.83 | MAPT (0.41) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL30343092 | 0.80 | GAA (0.62) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL127619 | 0.80 | GAA (0.62) | MAPTGAAKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6164775 | 0.79 | GAA (0.61) | MAPTGAAKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6550641 | 0.79 | GAA (0.61) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL6373230 | 0.77 | MAPT (0.50) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL31186986 | 0.75 | AHR (0.41) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL8470082 | 0.75 | CYP3A4 (0.47) | MAPTGAAALDH1A1HSD17B10NPC1 | |
| SCHEMBL8471521 | 0.75 | FABP6 (0.42) | MAPTGAAALDH1A1HSD17B10MAPK1 | |
| SCHEMBL8348569 | 0.75 | HSD17B10 (0.67) | MAPTGAAKMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |