Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23612317 | 0.77 | GAA (0.69) | GAAMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL10959070 | 0.76 | RAB9A (0.45) | LMNAALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL14341647 | 0.75 | SLC6A4 (0.47) | GAAADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL4259433 | 0.74 | HPGD (0.47) | GAALMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2023318 | 0.72 | SMN1; SMN2 (0.55) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6824016 | 0.72 | NPC1 (0.45) | GAAMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL10963231 | 0.71 | KDM4E (0.48) | MAPTLMNAALDH1A1KMT2ARAB9A | |
| SCHEMBL9732673 | 0.71 | FFAR1 (0.56) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL526383 | 0.69 | MAPT (0.58) | GAAADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL3093952 | 0.69 | MAPT (0.55) | ADRA2AADRA2BADRA2CMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085059-B1 | HETEROARYL COMPOUNDS AS INHIBITORS OF PROGRAMMED NECROSIS PATHWAY, COMPOSITION AND METHOD USING THE SAME | ACCRO BIOSCIENCE HK LTD (HK) | 2024-03-20 | — | — | EP | disclosed |