Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 16/20 | 0.52 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734070 | 0.88 | TRPV1 (0.51) | MALT1F10KDM4EMEN1TP53 | |
| SCHEMBL2382968 | 0.87 | PANK3 (0.47) | LIMK2 | |
| SCHEMBL2718828 | 0.81 | PANK3 (0.41) | LIMK2 | |
| SCHEMBL4562329 | 0.79 | KIT (0.41) | MEN1KMT2ALIMK2 | |
| SCHEMBL2719147 | 0.78 | PDGFRB (0.46) | LIMK2 | |
| SCHEMBL2381703 | 0.77 | PANK3 (0.43) | LIMK2 | |
| SCHEMBL2716482 | 0.77 | PI4KB (0.41) | LIMK2 | |
| SCHEMBL2717511 | 0.77 | PI4KB (0.53) | LIMK2 | |
| SCHEMBL2386385 | 0.76 | NPSR1 (0.41) | LIMK2 | |
| SCHEMBL2719957 | 0.76 | PANK3 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |