Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716871 | 0.89 | NPSR1 (0.47) | TRPV1TRPA1KCNH2TRPM8NPSR1 | |
| SCHEMBL2719291 | 0.89 | CNR2 (0.41) | TRPV1TRPA1KCNH2TRPM8NPSR1 | |
| SCHEMBL2718034 | 0.87 | CNR2 (0.44) | TRPV1TRPA1KCNH2TRPM8NPSR1 | |
| SCHEMBL2717511 | 0.87 | PI4KB (0.53) | TRPV1NPSR1HSD17B10 | |
| SCHEMBL2718774 | 0.86 | CNR2 (0.43) | TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2383318 | 0.86 | GAA (0.51) | TRPV1 | |
| SCHEMBL2384052 | 0.86 | LIMK2 (0.54) | HSD17B10 | |
| SCHEMBL2385769 | 0.85 | PDGFRB (0.44) | TRPV1NPSR1HSD17B10 | |
| SCHEMBL2730160 | 0.85 | TRPV1 (0.45) | TRPV1TRPA1KCNH2TRPM8NPSR1 | |
| SCHEMBL2720307 | 0.85 | TRPV1 (0.42) | TRPV1TRPA1KCNH2TRPM8NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |