Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718886 | 0.91 | CNR2 (0.40) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2718449 | 0.90 | CNR2 (0.40) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2716167 | 0.90 | GAA (0.41) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2719291 | 0.90 | CNR2 (0.41) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2719728 | 0.89 | MEN1 (0.40) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2716212 | 0.89 | CNR2 (0.39) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2730292 | 0.88 | TRPV1 (0.43) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL4561884 | 0.88 | RBP4 (0.40) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2716341 | 0.87 | RBP4 (0.39) | CNR2TRPV1TRPA1KCNH2TRPM8 | |
| SCHEMBL2730160 | 0.86 | TRPV1 (0.45) | CNR2TRPV1TRPA1KCNH2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | claimed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061337-A1 | FGFR2 MODULATORS | EXELIXIS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |