Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718520 | 0.87 | HTT (0.41) | HTTMAPK1TAAR1LMNASMN1; SMN2 | |
| SCHEMBL2718228 | 0.80 | MAP4K4 (0.42) | HTTMAPK1LMNASMN1; SMN2CDK5 | |
| SCHEMBL2719382 | 0.79 | PIK3CD (0.55) | CYP3A4PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2719011 | 0.76 | HTT (0.40) | HTTMAPK1TAAR1LMNASMN1; SMN2 | |
| SCHEMBL2721157 | 0.72 | HTR2A (0.40) | HTTTAAR1MAPTCDK8MEN1 | |
| SCHEMBL2717867 | 0.72 | PIK3CD (0.48) | MAP4K4CYP3A4PIK3CDPIK3CGPIK3CB | |
| SCHEMBL34460852 | 0.72 | HTT (1.00) | HTTMAPK1TAAR1LMNASMN1; SMN2 | |
| SCHEMBL2721364 | 0.71 | PIK3CD (0.51) | CYP3A4PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2717381 | 0.70 | PIK3CD (0.46) | HTTMAP4K4CDK8CYP3A4PIK3CD | |
| SCHEMBL2717253 | 0.70 | PIK3CD (0.46) | MAPK1LMNATSHRHSD17B10MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |