Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.34 |
| ▸ | RAF1 | P04049 | 5/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577427 | 0.94 | IRAK4 (0.38) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL29759708 | 0.92 | CCNT1 (0.35) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL24579079 | 0.92 | CCNT1 (0.35) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL29759922 | 0.90 | CCNT1 (0.35) | CCNT1CDK9POLQIRAK4IRAK1 | |
| SCHEMBL24579066 | 0.90 | CCNT1 (0.35) | CCNT1CDK9POLQIRAK4IRAK1 | |
| SCHEMBL24577464 | 0.90 | WNT3A (0.34) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL24577845 | 0.90 | POLQ (0.33) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL24578250 | 0.90 | WNT3A (0.34) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL24577437 | 0.89 | CCNT1 (0.36) | CCNT1CDK9POLQIRAK4RAF1 | |
| SCHEMBL29759926 | 0.89 | CCNT1 (0.36) | CCNT1CDK9POLQIRAK4RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | PDGFRA, PDGFRB, ABL1 | CCNT1 1550/4885CDK9 269/4885POLQ 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.