SCHEMBL27188449

SCHEMBL27188449

COc1cc(C)cc2cc(-c3nc(C4CCNC4)n4ncnc(N)c34)sc12

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 20/20 0.54
▸ FGFR3 P22607 19/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27188445 1.00 FGFR1 (0.54) FGFR1FGFR3
SCHEMBL27188424 0.84 FGFR2 (0.55) FGFR1FGFR3
SCHEMBL27188428 0.84 FGFR2 (0.55) FGFR1FGFR3
SCHEMBL30515776 0.84 FGFR2 (0.55) FGFR1FGFR3
SCHEMBL22132911 0.84 ACVRL1 (0.54) FGFR1FGFR3
SCHEMBL22132800 0.83 FGFR1 (0.68) FGFR1FGFR3
SCHEMBL15217930 0.81 FGFR1 (0.56) FGFR1FGFR3
SCHEMBL27188348 0.79 FGFR1 (0.59) FGFR1FGFR3
SCHEMBL27188422 0.79 FGFR4 (0.66) FGFR1FGFR3
SCHEMBL27188430 0.79 FGFR4 (0.66) FGFR1FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109896-A1 FGFR KINASE INHIBITOR AND USE THEREOF YA THERAPEUTICS INC (CN) 2024-04-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109896-A1 FGFR KINASE INHIBITOR AND USE THEREOF FGFR1, FGFR2, FGFR3 FGFR1 1/4885FGFR3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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