Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720072 | 0.90 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL3777095 | 0.79 | PIK3CD (0.82) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL2717715 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CBPIK3CACASP6 | |
| SCHEMBL15320448 | 0.77 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL6122150 | 0.76 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL2718941 | 0.76 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 | |
| SCHEMBL2717528 | 0.76 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CACASP6 | |
| SCHEMBL2720253 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2717781 | 0.76 | PIK3CD (0.40) | PIK3CDPIK3CGCASP6CYP2D6HTT | |
| SCHEMBL2718967 | 0.74 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CBPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |