Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717781 | 0.86 | PIK3CD (0.40) | PIK3CDPIK3CGCASP6METAP2METAP1 | |
| SCHEMBL2720072 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2717715 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CGCASP6MAP4K4METAP2 | |
| SCHEMBL2717418 | 0.79 | CBFB (0.44) | PIK3CDPIK3CGCASP6METAP2METAP1 | |
| SCHEMBL2717526 | 0.77 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2717145 | 0.76 | CBFB (0.44) | PIK3CDPIK3CGCASP6METAP2METAP1 | |
| SCHEMBL2717477 | 0.76 | CBFB (0.44) | PIK3CDPIK3CGCASP6METAP2METAP1 | |
| SCHEMBL2718969 | 0.76 | PIK3CD (0.53) | PIK3CDPIK3CGCASP6PIK3CBPIK3CA | |
| SCHEMBL3805286 | 0.74 | METAP2 (0.46) | PIK3CDPIK3CGCASP6METAP2METAP1 | |
| SCHEMBL2717695 | 0.72 | CBFB (0.44) | PIK3CDPIK3CGCASP6METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |