Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044086 | 0.79 | PARP1 (0.41) | TSHRALDH1A1ADRA1DPARP1PKM | |
| SCHEMBL4173670 | 0.76 | KDM4E (0.47) | ALDH1A1PARP1ESR1POLBSTAT3 | |
| SCHEMBL9390272 | 0.76 | PIK3CD (0.43) | TAAR1TSHRALDH1A1ADRA1DPIK3CD | |
| SCHEMBL14366318 | 0.74 | TSHR (0.46) | TAAR1TSHRALDH1A1ADRA1DPKM | |
| SCHEMBL11017320 | 0.72 | PKM (0.60) | TSHRALDH1A1PKMPOLBSMN1; SMN2 | |
| SCHEMBL7022414 | 0.72 | TAAR1 (0.47) | TAAR1TSHRADRA1DPIK3CDPIK3CB | |
| SCHEMBL28238591 | 0.71 | PARP1 (0.43) | TAAR1TSHRALDH1A1ADRA1DPARP1 | |
| SCHEMBL1543745 | 0.71 | CYP2C9 (0.39) | TAAR1TSHRALDH1A1ADRA1DPARP1 | |
| SCHEMBL3170350 | 0.71 | BACE1 (0.47) | TAAR1ALDH1A1POLBKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL15129169 | 0.71 | TAAR1 (0.45) | TAAR1TSHRADRA1DPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635572-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |