Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRNP | P04156 | 2/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720959 | 0.86 | DHODH (0.49) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1694918 | 0.82 | DHODH (0.39) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2718664 | 0.81 | SMN1; SMN2 (0.44) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2717879 | 0.81 | POLB (0.42) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2717114 | 0.81 | DHODH (0.57) | DHODHPRNPTACR3PLA2G2A | |
| SCHEMBL2719340 | 0.81 | DHODH (0.46) | DHODHPRNPPOLBMAPTMEN1 | |
| SCHEMBL2717134 | 0.78 | PDE5A (0.42) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2721075 | 0.77 | SMN1; SMN2 (0.43) | DHODHALDH1A1HPGDKDM4E | |
| SCHEMBL2719785 | 0.77 | PIK3CD (0.56) | DHODHPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2718353 | 0.75 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |