Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718713 | 0.87 | POLB (0.45) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2719493 | 0.84 | FABP3 (0.50) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2719340 | 0.81 | DHODH (0.46) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2719787 | 0.81 | DHODH (0.46) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2721870 | 0.80 | SMN1; SMN2 (0.47) | KDM4EALDH1A1HTTMAPTRXFP1 | |
| SCHEMBL2720125 | 0.79 | RORC (0.53) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2717114 | 0.77 | DHODH (0.57) | DHODHPRNP | |
| SCHEMBL2717296 | 0.74 | GNRHR (0.43) | KDM4EMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL2717878 | 0.74 | PIK3CD (0.43) | POLBKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL2718718 | 0.73 | PIK3CD (0.47) | POLBKDM4EMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |