Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717267 | 0.93 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717333 | 0.85 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2719956 | 0.83 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2719384 | 0.82 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2719807 | 0.82 | PIK3CD (0.73) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL3777601 | 0.81 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2717151 | 0.79 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2716654 | 0.79 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2718353 | 0.78 | PIK3CD (0.67) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 | |
| SCHEMBL2718432 | 0.78 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3CACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |