Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25041587 | 0.88 | TGM2 (0.53) | TGM2EGFRKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL28942945 | 0.84 | KCNQ3 (0.41) | TGM2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL31599360 | 0.82 | TGM2 (0.53) | TGM2EGFRGSTO1KDRMAOB | |
| SCHEMBL30241398 | 0.81 | TGM2 (0.60) | TGM2EGFRKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL23902633 | 0.81 | TGM2 (0.60) | TGM2EGFRKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL25042997 | 0.80 | TGM2 (0.53) | TGM2EGFRMCHR1CA12CA9 | |
| SCHEMBL27200996 | 0.78 | TGM2 (0.56) | TGM2EGFRMCHR1GSTO1 | |
| SCHEMBL27201013 | 0.77 | EGFR (0.45) | TGM2EGFRGSTO1 | |
| SCHEMBL30241458 | 0.77 | EGFR (0.45) | TGM2EGFRGSTO1 | |
| SCHEMBL26099479 | 0.76 | TGM2 (0.60) | TGM2EGFRKCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132907-B1 | (1H-INDOL-5-YL)ACRYLAMIDE DERIVATIVES AS INHIBITORS OF TEAD PROTEINS AND THE HIPPO-YAP1/TAZ SIGNALING CASCADE FOR THE TREATMENT OF CANCER | SANOFI SA (FR) | 2024-04-24 | — | — | EP | claimed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | claimed |
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | disclosed |
| EP-4132907-B1 | (1H-INDOL-5-YL)ACRYLAMIDE DERIVATIVES AS INHIBITORS OF TEAD PROTEINS AND THE HIPPO-YAP1/TAZ SIGNALING CASCADE FOR THE TREATMENT OF CANCER | SANOFI SA (FR) | 2024-04-24 | — | — | EP | disclosed |
| EP-4132907-A1 | (1 H-INDOL-5-YL)ACRYLAMIDE DERIVATIVES AS INHIBITORS OF TEAD PROTEINS AND THE HIPPO-YAP1/TAZ SIGNALING CASCADE FOR THE TREATMENT OF CANCER | SANOFI (FR) | 2023-02-15 | — | — | EP | disclosed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | disclosed |