Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720602 | 0.90 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A | |
| SCHEMBL2718187 | 0.90 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A | |
| SCHEMBL2717088 | 0.88 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A | |
| SCHEMBL2717207 | 0.85 | SMYD3 (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL2717642 | 0.84 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A | |
| SCHEMBL3776243 | 0.83 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2720104 | 0.83 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL6121716 | 0.80 | CBFB (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL2717536 | 0.79 | PDE10A (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A | |
| SCHEMBL6122848 | 0.79 | ALDH1A1 (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |