Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720230 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CBPIK3CABCL2 | |
| SCHEMBL15437102 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CBPIK3CABCL2 | |
| SCHEMBL15437009 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CBPIK3CABCL2 | |
| SCHEMBL2720154 | 0.75 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL15319860 | 0.74 | PIK3CG (0.53) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2720113 | 0.74 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2720069 | 0.73 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL6122226 | 0.72 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2719471 | 0.71 | LRRK2 (0.39) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL2718022 | 0.69 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |