Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720287 | 0.78 | POLB (0.37) | RAB9ATP53MAPK1CASP1CASP7 | |
| SCHEMBL6994900 | 0.74 | RAD52 (0.48) | RAD52SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL2720195 | 0.70 | NCEH1 (0.38) | SMN1; SMN2NPC1MAPTRAB9ANCEH1 | |
| SCHEMBL6989892 | 0.67 | CDYL (0.53) | RAD52KDM4EALDH1A1CDYL | |
| SCHEMBL10980763 | 0.66 | CYP1A2 (0.53) | RAD52SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8372934 | 0.65 | RAD52 (0.57) | RAD52NCEH1KDM4ERXFP1HPGD | |
| SCHEMBL10391564 | 0.65 | ALDH1A1 (0.46) | SMN1; SMN2NPC1MAPTRAB9ANCEH1 | |
| Potassium Ion SCHEMBL6991427 | 0.65 | RAD52 (0.41) | RAD52MAPTKDM4ERECQLHPGD | |
| SCHEMBL11571909 | 0.64 | ATM (0.47) | RAD52SMN1; SMN2KDM4ERECQLALDH1A1 | |
| SCHEMBL218139 | 0.64 | RAD52 (0.48) | RAD52NPC1MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |