Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131818 | 1.00 | CCR2 (0.45) | CCR2CHRNA7HTR3ATEAD1SFRP1 | |
| SCHEMBL2133483 | 0.93 | MCHR1 (0.44) | CCR2TEAD1SFRP1CYP2D6MCHR1 | |
| SCHEMBL2731955 | 0.93 | MCHR1 (0.44) | CCR2TEAD1SFRP1CYP2D6MCHR1 | |
| SCHEMBL2720564 | 0.93 | CHRNA7 (0.45) | CCR2CHRNA7TEAD1SFRP1MAP3K12 | |
| SCHEMBL2130918 | 0.93 | CHRNA7 (0.45) | CCR2CHRNA7TEAD1SFRP1MAP3K12 | |
| SCHEMBL2131092 | 0.91 | CCR2 (0.45) | CCR2RBP4CYP2D6MCHR1 | |
| SCHEMBL2722933 | 0.91 | CCR2 (0.45) | CCR2RBP4CYP2D6MCHR1 | |
| SCHEMBL2722386 | 0.88 | MCHR1 (0.42) | CCR2CHRNA7TEAD1SFRP1CYP2D6 | |
| SCHEMBL2130863 | 0.88 | MCHR1 (0.42) | CCR2CHRNA7TEAD1SFRP1CYP2D6 | |
| SCHEMBL2132298 | 0.86 | F2R (0.43) | CHRNA7SFRP1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630139-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-08-28 | — | — | EP | claimed |
| WO-2012054721-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICAL NV (BE) | 2012-04-26 | — | — | WO | claimed |