Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27203457 | 1.00 | NPC1 (0.48) | NPC1PKMMEN1KMT2AHSD17B10 | |
| SCHEMBL21694484 | 0.84 | MEN1 (0.43) | NPC1MEN1KMT2AHSD17B10MAOB | |
| SCHEMBL16474055 | 0.82 | MAPT (0.51) | MEN1KMT2AMAOBMAPTRAB9A | |
| SCHEMBL19985874 | 0.79 | MAOB (0.49) | MAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30956213 | 0.79 | NPC1 (0.43) | NPC1PKMMEN1KMT2AHSD17B10 | |
| SCHEMBL17267600 | 0.79 | HDAC7 (0.57) | KMT2AMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17267469 | 0.79 | HDAC7 (0.57) | KMT2AMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL17267471 | 0.79 | HDAC7 (0.57) | KMT2AMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29740550 | 0.79 | CHRM2 (0.57) | MEN1KMT2AMAOB | |
| SCHEMBL20472107 | 0.79 | CHRM2 (0.57) | MEN1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132517-A1 | MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | GOHARMONY THERAPEUTICS (SHENZHEN) CO., LTD. (CN) | 2024-04-25 | — | — | US | disclosed |
| WO-2022171139-A1 | MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | 北京国鸿生物医药科技有限公司 | 2022-08-18 | — | — | WO | disclosed |
| CN-110950890-B | Substituted imidazo [4,5-c ] quinoline macrocycles as multi-target kinase inhibitors | 北京赛林泰医药技术有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110950890-A | Substituted imidazo [4,5-c ] quinoline macrocycles as multi-target kinase inhibitors | 北京赛林泰医药技术有限公司 | 2020-04-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132517-A1 | MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | SRC, FLT3, BRAF | NPC1 778/4885PKM 125/4885MEN1 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.