Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.37 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719784 | 0.83 | CBFB (0.36) | MEN1KMT2ARXFP1CCR1CCR5 | |
| SCHEMBL2720791 | 0.81 | PADI4 (0.40) | MEN1KMT2APOLBCCR1CCR5 | |
| SCHEMBL2717724 | 0.80 | HAVCR2 (0.42) | NR1H2NR1H3HAVCR2NR4A2PPARG | |
| SCHEMBL2719772 | 0.80 | TAAR1 (0.42) | NR1H2NR1H3HAVCR2NR4A2PPARG | |
| SCHEMBL2720744 | 0.72 | HAVCR2 (0.50) | NR1H2NR1H3HAVCR2PPARGMEN1 | |
| SCHEMBL2718454 | 0.72 | METAP2 (0.40) | PARP1LMNANPSR1METAP1 | |
| SCHEMBL2719771 | 0.71 | PIK3CD (0.43) | NR1H2NR1H3HAVCR2NR4A2MEN1 | |
| SCHEMBL2719760 | 0.68 | NR1H2 (0.36) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL5325012 | 0.67 | KDM4E (0.59) | POLBCCR1CCR5CCR8MAPK14 | |
| SCHEMBL2719426 | 0.67 | PARP1 (0.39) | MEN1KMT2AAURKAPRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |