Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720785 | 0.86 | CBFB (0.37) | TAAR1TDP1MEN1ALDH1A1KMT2A | |
| SCHEMBL2719760 | 0.82 | NR1H2 (0.36) | TAAR1CTDSP1TDP1NR1H2NR1H3 | |
| SCHEMBL2721157 | 0.79 | HTR2A (0.40) | TAAR1CTDSP1TDP1MEN1ALDH1A1 | |
| SCHEMBL4102196 | 0.77 | JAK2 (0.40) | ALOX5APFEN1CTDSP1TDP1NR1H2 | |
| SCHEMBL2720943 | 0.77 | JAK2 (0.40) | ALOX5APFEN1CTDSP1TDP1NR1H2 | |
| SCHEMBL2718747 | 0.74 | FFAR1 (0.36) | TAAR1ALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL2719758 | 0.73 | CCNB2 (0.43) | ALOX5APFEN1NR1H2NR1H3PPARA | |
| SCHEMBL2719830 | 0.72 | LOXL2 (0.42) | TAAR1MEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2721134 | 0.70 | PRKAA2 (0.40) | TAAR1ALDH1A1HPGDL3MBTL1TP53 | |
| SCHEMBL2719784 | 0.69 | CBFB (0.36) | MEN1ALDH1A1HPGDKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |