Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29564063 | 1.00 | GCK (0.46) | GCKTDP1RXRBMRGPRX2ALDH1A1 | |
| SCHEMBL31510724 | 0.88 | MRGPRX2 (0.41) | GCKTDP1MRGPRX2ALDH1A1RAB9A | |
| SCHEMBL29564421 | 0.88 | MRGPRX2 (0.41) | GCKTDP1MRGPRX2ALDH1A1RAB9A | |
| SCHEMBL27211459 | 0.88 | MRGPRX2 (0.41) | GCKTDP1MRGPRX2ALDH1A1RAB9A | |
| SCHEMBL27211262 | 0.83 | GCK (0.46) | GCKTDP1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29563807 | 0.81 | HRH3 (0.42) | RXRBMRGPRX2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29563905 | 0.81 | JAK2 (0.42) | GCKALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL31132482 | 0.81 | CARM1 (0.43) | TDP1MRGPRX2ALDH1A1TP53KDR | |
| SCHEMBL29564440 | 0.81 | MRGPRX2 (0.42) | TDP1MRGPRX2 | |
| SCHEMBL27211370 | 0.81 | MRGPRX2 (0.42) | TDP1MRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11976057-B2 | MrgX2 antagonists | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2024-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11976057-B2 | MrgX2 antagonists | MRGPRX2, MRGPRX1, MRGPRX4 | GCK 3694/4885TDP1 4070/4885RXRB 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.