Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.83 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24857240 | 1.00 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| Hydrochloric Acid SCHEMBL31187786 | 0.95 | KRAS (0.76) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL27212496 | 0.94 | KRAS (0.84) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL24857246 | 0.94 | KRAS (0.84) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL24858310 | 0.94 | KRAS (0.81) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25136743 | 0.94 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25136725 | 0.94 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL28906506 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL28906532 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25136934 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119522222-A | Nitrogen-containing heterocyclic compound, preparation method thereof, intermediate thereof and application thereof | 上海艾力斯医药科技股份有限公司 | 2025-02-25 | — | — | CN | disclosed |
| US-20240368192-A1 | Nitrogen-Containing Heterocyclic Compound, and Preparation Method Therefor, Intermediate Thereof, and Application Thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-11-07 | — | — | US | disclosed |
| CN-118679170-A | Nitrogen-containing heterocyclic compound, and preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-118434747-A | Nitrogen-containing heterocyclic compound, preparation method, intermediate and application thereof | 上海艾力斯医药科技股份有限公司 | 2024-08-02 | — | — | CN | disclosed |
| EP-4365178-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND APPLICATION THEREOF | Shanghai Allist Pharmaceuticals Co., Ltd. (CN) | 2024-05-08 | — | — | EP | disclosed |
| CN-117642407-A | Nitrogen-containing heterocyclic compound, preparation method, intermediate and application thereof | 上海艾力斯医药科技股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368192-A1 | Nitrogen-Containing Heterocyclic Compound, and Preparation Method Therefor, Intermediate Thereof, and Application Thereof | KRAS, NRAS, HRAS | KRAS 1/4885MAPK3 667/4885MAPK1 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.