SCHEMBL27214765

SCHEMBL27214765

Fc1cc(F)cc(C#Cc2ccc(C#Cc3cc(F)cc(F)c3)cc2)c1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.44
CA12 O43570 3/20 0.42
CA1 P00915 3/20 0.42
CA9 Q16790 3/20 0.42
CA2 P00918 2/20 0.42
APP P05067 3/20 0.41
FFAR1 O14842 1/20 0.36
NTRK3 Q16288 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20813871 0.88 GRM5 (0.47) GRM5CA12CA1CA9CA2
SCHEMBL6369908 0.87 APP (0.60) GRM5CA12CA1CA9CA2
SCHEMBL17104746 0.82 SNCA (0.52) APP
SCHEMBL20212084 0.82 GRM5 (0.50) GRM5CA12CA1CA9CA2
SCHEMBL4460258 0.81 GRM5 (0.50) GRM5CA12CA9CA2
SCHEMBL7717366 0.78 GRM5 (0.50) GRM5CA12CA1CA9CA2
SCHEMBL10300106 0.78 GRM5 (0.50) GRM5CA12CA1CA9CA2
SCHEMBL718949 0.78 GRM5 (0.50) GRM5CA12CA1CA9CA2
Charcoal, Activated SCHEMBL31286307 0.75 GRM5 (0.48) GRM5CA12CA1CA9CA2
Fluoride SCHEMBL31286313 0.75 GRM5 (0.48) GRM5CA12CA1CA9CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240151993-A1 ELECTRON WITHDRAWING GROUP (EWG)-CONTAINING ORGANIC MOLECULES FOR IMPROVED OPTICAL PROPERTIES IN AR/VR COMPONENTS META PLATFORMS TECHNOLOGIES, LLC 2024-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240151993-A1 ELECTRON WITHDRAWING GROUP (EWG)-CONTAINING ORGANIC MOLECULES FOR IMPROVED OPTICAL PROPERTIES IN AR/VR COMPONENTS AR, OR10J3, ESRRG GRM5 548/4885CA12 1442/4885CA1 2106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.