Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 8/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27224372 | 0.77 | GRIN2B (0.56) | GRIN2B | |
| SCHEMBL22772854 | 0.76 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL29465730 | 0.76 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL27224374 | 0.76 | GRIN2B (0.58) | GRIN2B | |
| SCHEMBL27224375 | 0.75 | GRIN2B (0.60) | GRIN2B | |
| SCHEMBL24263651 | 0.67 | HDAC6 (0.60) | GRIN2BADORA3DHODHSCN10ANPC1 | |
| SCHEMBL27996626 | 0.66 | SCN10A (0.61) | ADORA3SCN10AABL1BCRSCN2A | |
| SCHEMBL6311026 | 0.65 | MAPT (0.48) | GRIN2BADORA3DHODHNPC1MAPT | |
| SCHEMBL1758365 | 0.65 | ABL1 (0.57) | ADORA3SCN10ACYP1A2NPC1MAPT | |
| SCHEMBL27745191 | 0.65 | DHODH (0.46) | GRIN2BADORA3DHODHSCN10ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993587-B2 | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2024-05-28 | — | — | US | claimed |
| CN-114008052-A | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114008052-A | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993587-B2 | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN2C | GRIN2B 1/4885SCN5A 197/4885ADORA3 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.