Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28699350 | 0.79 | GRIN2B (0.53) | GRIN2BGRIN1CYP2D6 | |
| SCHEMBL29465727 | 0.75 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL22772880 | 0.75 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL27224368 | 0.75 | GRIN2B (0.61) | GRIN2B | |
| SCHEMBL27224374 | 0.74 | GRIN2B (0.58) | GRIN2B | |
| SCHEMBL27224372 | 0.74 | GRIN2B (0.56) | GRIN2B | |
| SCHEMBL21611130 | 0.68 | GRIN2B (0.61) | GRIN2BGRIN1CYP2D6 | |
| SCHEMBL28687512 | 0.66 | GRIN2B (0.55) | GRIN2BGRIN1 | |
| SCHEMBL28736242 | 0.65 | GRIN1 (0.65) | GRIN2BGRIN1CYP2D6 | |
| SCHEMBL30015038 | 0.64 | GRIN2B (0.44) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993587-B2 | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2024-05-28 | — | — | US | claimed |
| CN-114008052-A | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114008052-A | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993587-B2 | Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN2C | GRIN2B 1/4885GRIN1 5/4885CYP2D6 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.